Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling
نویسندگان
چکیده
منابع مشابه
Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling.
Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of receptors, including their structures and interactions with Wnt proteins, and signaling mechanisms from receptor activation to the engagement of intracellular partners Dishevelled and Axin, and finally to the inhibitio...
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Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseas...
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Wnt/β-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs). Because little information is available about the function of Frizzled receptors (Fzds) as the main receptors of Wnt proteins in hMSCs, we first performed comparative Fzd mRNA expression profiling. Fzd9 and Fzd10 were not expres...
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will break the barrier, making the TJ a frequent contributor to a vast range of pathologies of blood vessels and epithelial organs. Since most of these insults have pleotropic cellular effects, it is difficult to envision therapies that could target specific TJ components or functions. In contrast, some assaults on the barrier are quite specific. For example, house dust mites excrete a fecal pr...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2012
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a007880